The adaptive immune system of jawed vertebrates generates a highly diverse repertoire of antibodies to meet the antigenic challenges of a constantly evolving biological ecosystem.Most of the diversity is generated by two mechanisms: V(D)J gene recombination and somatic hypermutation (SHM).SHM introduces changes in the variable domain of antibodies,
Abstract Translationally controlled tumor protein (TCTP) is expressed in many tissues, particularly in human tumors.It plays a role in malignant transformation, apoptosis prevention, and DNA damage repair.The signaling mechanisms underlying TCTP regulation in cancer are only partially understood.Here, we investigated the role of mTORC1 in regulatin
With the promotion of energy transformation, the utilization ratio of electrical power is progressively rising.Since electrical power is challenging to store, real-time production and consumption become imperative, imposing significant demands on the dependability and operational efficiency of electrical power apparatus.Suppose the load distributio
We report a case of a 55-year-old male admitted for cardiogenic embolic Oral Care ischemic stroke work up.A transesophageal (TE) echocardiography (E) with contrast study to rule out patent foramen ovale (PFO) was performed; two-dimensional (2D) analysis did not detect any bubbles passage during Valsalva manoeuvre in the standard 2D cross sectional